Transcriptome-Wide N6-Methyladenosine Alternations in Pulmonary Arteries of Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats and Novel Therapeutic Targets.

ABSTRACT: N6-methyladenosine (m⁶A) is a post-transcriptional epigenetic change with transcriptional stability and functionality regulated by specific m⁶A-modifying enzymes. However, the significance of genes modified by m⁶A and enzymes specific to m⁶A regulation in the context of pulmonary arterial hypertension (PAH) remains largely unexplored. MeRIP-seq and RNA-seq were applied to explore variances in m⁶A and RNA expression within the pulmonary artery tissues of control and monocrotaline-induced PAH rats. Functional enrichments were analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. To screen candidate m⁶A-related genes, the STRING and Metascape databases were used to construct a protein-protein interaction

SUBMITTER: Feng Y 

PROVIDER: S-EPMC10886831 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature