Mitochondria-Targeted Catalase Does Not Suppress Development of Cellular Senescence during Aging.

ABSTRACT: Cellular senescence is a complex stress response marked by stable proliferative arrest and the secretion of biologically active molecules collectively known as the senescence-associated secretory phenotype (SASP). Mitochondria-derived reactive oxygen species (ROS) have been implicated in aging and age-related processes, including senescence. Stressors that increase ROS levels promote both senescence and the SASP, while reducing mitochondrial ROS or mitochondria themselves can prevent senescence or the SASP. Mitochondrially targeted catalase (mCAT), a transgene that reduces mitochondrial levels of ROS, has been shown to extend the lifespan of murine models and protect against the age-related loss of mitochondrial function. However, it remains unclear whether mCAT can prevent senescence or t

SUBMITTER: Mogck BA 

PROVIDER: S-EPMC10886841 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature