Treatment with Cobra Venom Factor Decreases Ischemic Tissue Damage in Mice.

ABSTRACT: Tissue ischemia, caused by the blockage of blood vessels, can result in substantial damage and impaired tissue performance. Information regarding the functional contribution of the complement system in the context of ischemia and angiogenesis is lacking. To investigate the influence of complement activation and depletion upon femoral artery ligation (FAL), Cobra venom factor (CVF) (that functionally resembles C3b, the activated form of complement component C3) was applied in mice in comparison to control mice. Seven days after induction of muscle ischemia through FAL, gastrocnemius muscles of mice were excised and subjected to (immuno-)histological analyses. H&E and apoptotic cell staining (TUNEL) staining revealed a significant reduction in ischemic tissue damage in CVF-treated mice compa

SUBMITTER: Azubuike-Osu SO 

PROVIDER: S-EPMC10886846 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature