Genetic and Epigenetic Aspects of Type 1 Diabetes Mellitus: Modern View on the Problem.

ABSTRACT: Omics technologies accumulated an enormous amount of data that advanced knowledge about the molecular pathogenesis of type 1 diabetes mellitus and identified a number of fundamental problems focused on the transition to personalized diabetology in the future. Among them, the most significant are the following: (1) clinical and genetic heterogeneity of type 1 diabetes mellitus; (2) the prognostic significance of DNA markers beyond the HLA genes; (3) assessment of the contribution of a large number of DNA markers to the polygenic risk of disease progress; (4) the existence of ethnic population differences in the distribution of frequencies of risk alleles and genotypes; (5) the infancy of epigenetic research into type 1 diabetes mellitus. Disclosure of these issues is one of the prior

SUBMITTER: Minniakhmetov I 

PROVIDER: S-EPMC10886892 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature