Cell-Free DNA 5-Hydroxymethylcytosine Signatures for Lung Cancer Prognosis.

ABSTRACT: Accurate prognostic markers are essential for guiding effective lung cancer treatment strategies. The level of 5-hydroxymethylcytosine (5hmC) in tissue is independently associated with overall survival (OS) in lung cancer patients. We explored the prognostic value of cell-free DNA (cfDNA) 5hmC through genome-wide analysis of 5hmC in plasma samples from 97 lung cancer patients. In both training and validation sets, we discovered a cfDNA 5hmC signature significantly associated with OS in lung cancer patients. We built a 5hmC prognostic model and calculated the weighted predictive scores (wp-score) for each sample. Low wp-scores were significantly associated with longer OS compared to high wp-scores in the training [median 22.9 versus 8.2 months; p = 1.30 × 10^-10; hazard rat

SUBMITTER: Shao J 

PROVIDER: S-EPMC10886903 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature