Developmental Dyslexia: Insights from EEG-Based Findings and Molecular Signatures-A Pilot Study.

ABSTRACT: Developmental dyslexia (DD) is a learning disorder. Although risk genes have been identified, environmental factors, and particularly stress arising from constant difficulties, have been associated with the occurrence of DD by affecting brain plasticity and function, especially during critical neurodevelopmental stages. In this work, electroencephalogram (EEG) findings were coupled with the genetic and epigenetic molecular signatures of individuals with DD and matched controls. Specifically, we investigated the genetic and epigenetic correlates of key stress-associated genes (NR3C1, NR3C2, FKBP5, GILZ, SLC6A4) with psychological characteristics (depression, anxiety, and stress) often included in DD diagnostic criteria, as well as with brain EEG findings.

SUBMITTER: Theodoridou D 

PROVIDER: S-EPMC10887023 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature