CRISPR-Cas9 base editors and their current role in human therapeutics.

ABSTRACT:

Background

Consistent progress has been made to create more efficient and useful CRISPR-Cas9-based molecular toolsfor genomic modification.

Methods

This review focuses on recent articles that have employed base editors (BEs) for both clinical and research purposes.

Results

CRISPR-Cas9 BEs are a useful system because of their highefficiency and broad applicability to gene correction and disruption. In addition, base editing has beensuggested as a safer approach than other CRISPR-Cas9-based systems, as it limits double-strand breaksduring multiplex gene knockout and does not require a toxic DNA donor molecule for genetic correction.

Conclusion

As such, numerous industry and academic groups are currently developing base editing strategies withclinical applications

SUBMITTER: Lahr WS 

PROVIDER: S-EPMC10887149 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature