Specific Multiomic Profiling in Aortic Stenosis in Bicuspid Aortic Valve Disease.

ABSTRACT:

Introduction and purpose

Bicuspid aortic valve (BAV) disease is associated with faster aortic valve degeneration and a high incidence of aortic stenosis (AS). In this study, we aimed to identify differences in the pathophysiology of AS between BAV and tricuspid aortic valve (TAV) patients in a multiomics study integrating metabolomics and transcriptomics as well as clinical data.

Methods

Eighteen patients underwent aortic valve replacement due to severe aortic stenosis: 8 of them had a TAV, while 10 of them had a BAV. RNA sequencing (RNA-seq) and proton nuclear magnetic resonance spectroscopy (1H-NMR) were performed on these tissue samples to obtain the RNA profile and lipid and low-molecular-weight metabolites. These results combined with clinical data were posteriorly comp

SUBMITTER: Antequera-Gonzalez B 

PROVIDER: S-EPMC10887224 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature