MicroRNAs: Potential prognostic and theranostic biomarkers in chronic lymphocytic leukemia.

ABSTRACT: Small noncoding ribonucleic acids called microRNAs coordinate numerous critical physiological and biological processes such as cell division, proliferation, and death. These regulatory molecules interfere with the function of many genes by binding the 3'-UTR region of target mRNAs to inhibit their translation or even degrade them. Given that a large proportion of miRNAs behave as either tumor suppressors or oncogenes, any genetic or epigenetic aberration changeing their structure and/or function could initiate tumor formation and development. An example of such cancers is chronic lymphocytic leukemia (CLL), the most prevalent adult leukemia in Western nations, which is caused by unregulated growth and buildup of defective cells in the peripheral blood and lymphoid organs. Genetic alteratio

SUBMITTER: Ali A 

PROVIDER: S-EPMC10887358 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature