PCP and Septins govern the polarized organization of the actin cytoskeleton during convergent extension.

ABSTRACT: Convergent extension (CE) requires the coordinated action of the planar cell polarity (PCP) proteins^1,2 and the actin cytoskeleton,^3,4,5,6 but this relationship remains incompletely understood. For example, PCP signaling orients actomyosin contractions, yet actomyosin is also required for the polarized localization of PCP proteins.^7,8 Moreover, the actin-regulating Septins play key roles in actin organization⁹ and are implicated in PCP and CE in frogs, mice, and fish^5,6,10,11,12 but execute only a subset of PCP-dependent cell behaviors. Sept

SUBMITTER: Devitt CC 

PROVIDER: S-EPMC10887425 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature