New Derivatives of 1-(3-Methyl-1-Benzofuran-2-yl)Ethan-1-one: Synthesis and Preliminary Studies of Biological Activity.

ABSTRACT: A set of nine derivatives, including five brominated compounds, was synthesized and the structures of these novel compounds were confirmed using ¹H and ¹³C NMR as well as ESI MS spectra. These compounds were tested on four different cancer cell lines, chronic myelogenous leukemia (K562), prostate cancer (PC3), colon cancer (SW620), human kidney cancer (Caki 1), and on healthy human keratocytes (HaCaT). MTT results reveal that two newly developed derivatives (6 and 8) exhibit selective action towards K562 cells and no toxic effect in HaCat cells. The biological activity of these two most promising compounds was evaluated by trypan blue assay, reactive oxygen species generation, and IL-6 secretion. To investigate the proapoptotic activity of selected compo

SUBMITTER: Napiorkowska M 

PROVIDER: S-EPMC10888192 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature