Cognitive Function Is Associated with the Genetically Determined Efficiency of DNA Repair Mechanisms.

ABSTRACT: Several modifiable risk factors for neurodegeneration and dementia have been identified, although individuals vary in their vulnerability despite a similar risk of exposure. This difference in vulnerability could be explained at least in part by the variability in DNA repair mechanisms' efficiency between individuals. Therefore, the aim of this study was to test associations between documented, prevalent genetic variation (single nucleotide polymorphism, SNP) in DNA repair genes, cognitive function, and brain structure. Community-living participants (n = 488,159; 56.54 years (8.09); 54.2% female) taking part in the UK Biobank study and for whom cognitive and genetic measures were available were included. SNPs in base excision repair (BER) genes of the bifunctional DNA glycosylases <

SUBMITTER: Cherbuin N 

PROVIDER: S-EPMC10888195 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature