Theoretical Improvements in Enzyme Efficiency Associated with Noisy Rate Constants and Increased Dissipation.

ABSTRACT: Previous studies have revealed the extraordinarily large catalytic efficiency of some enzymes. High catalytic proficiency is an essential accomplishment of biological evolution. Natural selection led to the increased turnover number, k_cat, and enzyme efficiency, k_cat/K_M, of uni-uni enzymes, which convert a single substrate into a single product. We added or multiplied random noise with chosen rate constants to explore the correlation between dissipation and catalytic efficiency for ten enzymes: beta-galactosidase, glucose isomerase, β-lactamases from three bacterial strains, ketosteroid isomerase, triosephosphate isomerase, and carbonic anhydrase I, II, and T200H. Our results highlight the role of biological evolution in accelerating thermodynamic evolution

SUBMITTER: Juretic D 

PROVIDER: S-EPMC10888251 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature