New Perspectives of Therapies in Osteogenesis Imperfecta-A Literature Review.

ABSTRACT: (1) Background: Osteogenesis imperfecta (OI) is a rare skeletal dysplasia characterized as a heterogeneous disorder group with well-defined phenotypic and genetic features that share uncommon bone fragility. The current treatment options, medical and orthopedic, are limited and not efficient enough to improve the low bone density, bone fragility, growth, and mobility of the affected individuals, creating the need for alternative therapeutic agents. (2) Methods: We searched the medical database to find papers regarding treatments for OI other than conventional ones. We included 45 publications. (3) Results: In reviewing the literature, eight new potential therapies for OI were identified, proving promising results in cells and animal models or in human practice, but further research is stil

SUBMITTER: Dinulescu A 

PROVIDER: S-EPMC10888533 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature