Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2 and ADAMTS-12.

ABSTRACT: Interaction between extracellular matrix (ECM) components plays an important role in the regulation of cellular behavior and hence in tissue function. Consequently, characterization of new interactions within ECM opens the possibility of studying not only the functional but also the pathological consequences derived from those interactions. We have previously described the interaction between fibulin2 and ADAMTS-12 in vitro and the effects of that interaction using cellular models of cancer. Now, we generate a mouse deficient in both ECM components and evaluate functional consequences of their absence using different cancer and inflammation murine models. The main findings indicate that mice deficient in both fibulin2 and ADAMTS12 markedly increase the development of lung tumors following

SUBMITTER: Mohamedi Y 

PROVIDER: S-EPMC10888546 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature