Arsenic Impairs Wound Healing Processes in Dermal Fibroblasts and Mice.

ABSTRACT: Inorganic arsenic (NaAsO₂) is a naturally occurring metalloid found in water resources globally and in the United States at concentrations exceeding the U.S. Environmental Protection Agency Maximum Contamination Level of 10 ppb. While exposure to arsenic has been linked to cancer, cardiovascular disease, and skin lesions, the impact of arsenic exposure on wound healing is not fully understood. Cultured dermal fibroblasts exposed to NaAsO₂ displayed reduced migration (scratch closure), proliferation, and viability with a lowest observable effect level (LOEL) of 10 µM NaAsO₂ following 24 h exposure. An enrichment of Matrix Metalloproteinase 1 (MMP1) transcripts was observed at a LOEL of 1 µM NaAsO₂ and 24 h exposure_. In vivo, C57B

SUBMITTER: Dresler SR 

PROVIDER: S-EPMC10888720 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature