Investigation of the General Molecular Mechanisms of Gallic Acid via Analyses of Its Transcriptome Profile.

ABSTRACT: Gallic acid (GA), a phenolic compound naturally found in many plants, exhibits potential preventive and therapeutic roles. However, the underlying molecular mechanisms of its diverse biological activities remain unclear. Here, we investigated possible mechanisms of GA function through a transcriptome-based analysis using LINCS L1000, a publicly available data resource. We compared the changes in the gene expression profiles induced by GA with those induced by FDA-approved drugs in three cancer cell lines (A549, PC3, and MCF7). The top 10 drugs exhibiting high similarity with GA in their expression patterns were identified by calculating the connectivity score in the three cell lines. We specified the known target proteins of these drugs, which could be potential targets of GA, and identifi

SUBMITTER: Kim J 

PROVIDER: S-EPMC10888745 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature