Metabolites that feed upper glycolytic branches support glucose independent human cytomegalovirus replication.

ABSTRACT: The broad tissue distribution and cell tropism of human cytomegalovirus indicates that the virus successfully replicates in tissues with various nutrient environments. HCMV requires and reprograms central carbon metabolism for viral replication. However, many studies focus on reprogramming of metabolism in high nutrient conditions that do not recapitulate physiological nutrient environments in the body. In this study, we investigate how HCMV successfully replicates when nutrients are suboptimal. We limited glucose following HCMV infection to determine how glucose supports virus replication and how nutrients potentially present in the physiological environment contribute to successful glucose independent HCMV replication. Glucose is required for HCMV viral genome synthesis, viral protein pr

SUBMITTER: Mokry RL 

PROVIDER: S-EPMC10888764 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature