Overcoming the "feast or famine" effect: improved interaction testing in genome-wide association studies.

ABSTRACT: In genetic association analysis of complex traits, detection of interaction (either GxG or GxE) can help to elucidate the genetic architecture and biological mechanisms underlying the trait. Detection of interaction in a genome-wide interaction study (GWIS) can be methodologically challenging for various reasons, including a high burden of multiple comparisons when testing for epistasis between all possible pairs of a set of genomewide variants, as well as heteroscedasticity effects occurring in the presence of GxG or GxE interaction. In this paper, we address the problem of an even more striking phenomenon that we call the "feast or famine" effect that occurs when testing interaction in a genomewide context. We show that in any given GxE GWIS, the type 1 error of standard interaction test

SUBMITTER: Zhou H 

PROVIDER: S-EPMC10888770 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature