Influence of insulin sensitivity on food cue evoked functional brain connectivity in children.

ABSTRACT:

Objective

Insulin resistance during childhood is a risk factor for developing type 2 diabetes and other health problems later in life. Studies in adults have shown that insulin resistance affects regional and network activity in the brain which are vital for behavior, e.g. ingestion and metabolic control. To date, no study has investigated whether brain responses to food cues in children are associated with peripheral insulin sensitivity.

Methods

We included 53 children (36 girls) between the age of 7-11 years, who underwent an oral Glucose Tolerance Test (oGTT) to estimate peripheral insulin sensitivity (ISI). Brain responses were measured using functional magnetic resonance imaging (fMRI) before and after glucose ingestion. We compared food-cue task-based activity and func

SUBMITTER: Semeia L 

PROVIDER: S-EPMC10888780 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature