Circadian rhythms of macrophages are altered by the acidic pH of the tumor microenvironment.

ABSTRACT: Macrophages are prime therapeutic targets due to their pro-tumorigenic and immunosuppressive functions in tumors, but varying efficacy of therapeutic approaches targeting macrophages highlights our incomplete understanding of how the tumor microenvironment (TME) can influence regulation of macrophages. The circadian clock is a key internal regulator of macrophage function, but how circadian rhythms of macrophages may be influenced by the tumor microenvironment remains unknown. We found that conditions associated with the TME such as polarizing stimuli, acidic pH, and elevated lactate concentrations can each alter circadian rhythms in macrophages. Circadian rhythms were enhanced in pro-resolution macrophages but suppressed in pro-inflammatory macrophages, while acidic pH had divergent effec

SUBMITTER: Knudsen-Clark AM 

PROVIDER: S-EPMC10888792 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature