New Obolenskvirus Phages Brutus and Scipio: Biology, Evolution, and Phage-Host Interaction.

ABSTRACT: Two novel virulent phages of the genus Obolenskvirus infecting Acinetobacter baumannii, a significant nosocomial pathogen, have been isolated and studied. Phages Brutus and Scipio were able to infect A. baumannii strains belonging to the K116 and K82 capsular types, respectively. The biological properties and genomic organization of the phages were characterized. Comparative genomic, phylogenetic, and pangenomic analyses were performed to investigate the relationship of Brutus and Scipio to other bacterial viruses and to trace the possible origin and evolutionary history of these phages and other representatives of the genus Obolenskvirus. The investigation of enzymatic activity of the tailspike depolymerase encoded in the genome of phage Scipio, the first repor

SUBMITTER: Evseev PV 

PROVIDER: S-EPMC10888812 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature