Molecular signatures of cortical expansion in the human fetal brain.

ABSTRACT: The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. A growing catalogue of cells in the prenatal brain has revealed remarkable molecular diversity across cortical areas.^1,2 Despite this, little is known about how this translates into the patterns of differential cortical expansion observed in humans during the latter stages of gestation. Here we present a new resource, μBrain, to facilitate knowledge translation between molecular and anatomical descriptions of the prenatal developing brain. Built using generative artificial intelligence, μBrain is a three-dimensional cellular-resolution digital atlas combining publicly-available serial sections of the postmortem human brain at 21 weeks gestation³ with b

SUBMITTER: Ball G 

PROVIDER: S-EPMC10888819 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature