Ramping cells in rodent mPFC encode time to past and future events via real Laplace transform.

ABSTRACT: In interval reproduction tasks, animals must remember the event starting the interval and anticipate the time of the planned response to terminate the interval. The interval reproduction task thus allows for studying both memory for the past and anticipation of the future. We analyzed previously published recordings from rodent mPFC (Henke et al., 2021) during an interval reproduction task and identified two cell groups by modeling their temporal receptive fields using hierarchical Bayesian models. The firing in the "past cells" group peaked at the start of the interval and relaxed exponentially back to baseline. The firing in the "future cells" group increased exponentially and peaked right before the planned action at the end of the interval. Contrary to the previous assumption that timi

SUBMITTER: Cao R 

PROVIDER: S-EPMC10888827 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature