Complementary Cytoskeletal Feedback Loops Control Signal Transduction Excitability and Cell Polarity.

ABSTRACT: To move through complex environments, cells must constantly integrate chemical and mechanical cues. Signaling networks, such as those comprising Ras and PI3K, transmit chemical cues to the cytoskeleton, but the cytoskeleton must also relay mechanical information back to those signaling systems. Using novel synthetic tools to acutely control specific elements of the cytoskeleton in Dictyostelium and neutrophils, we delineate feedback mechanisms that alter the signaling network and promote front- or back-states of the cell membrane and cortex. First, increasing branched actin assembly increases Ras/PI3K activation while reducing polymeric actin levels overall decreases activation. Second, reducing myosin II assembly immediately increases Ras/PI3K activation and sensitivity to chemotac

SUBMITTER: Kuhn J 

PROVIDER: S-EPMC10888828 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature