50,000 years of Evolutionary History of India: Insights from ~2,700 Whole Genome Sequences.

ABSTRACT: India has been underrepresented in whole genome sequencing studies. We generated 2,762 high coverage genomes from India-including individuals from most geographic regions, speakers of all major languages, and tribal and caste groups-providing a comprehensive survey of genetic variation in India. With these data, we reconstruct the evolutionary history of India through space and time at fine scales. We show that most Indians derive ancestry from three ancestral groups related to ancient Iranian farmers, Eurasian Steppe pastoralists and South Asian hunter-gatherers. We uncover a common source of Iranian-related ancestry from early Neolithic cultures of Central Asia into the ancestors of Ancestral South Indians (ASI), Ancestral North Indians (ANI), Austro-asiatic-related and East Asian-relate

SUBMITTER: Kerdoncuff E 

PROVIDER: S-EPMC10888882 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature