HIV-1 Mediated Cortical Actin Disruption Mirrors ARP2/3 Defects Found in Primary T Cell Immunodeficiencies.

ABSTRACT: During cell movement, cortical actin balances mechanical and osmotic forces to maintain cell function while providing the scaffold for cell shape. Migrating CD4⁺ T cells have a polarized structure with a leading edge containing dynamic branched and linear F-actin structures that bridge intracellular components to surface adhesion molecules. These actin structures are complemented with a microtubular network beaded with membrane bound organelles in the trailing uropod. Disruption of actin structures leads to dysregulated migration and changes in morphology of affected cells. In HIV-1 infection, CD4⁺ T cells have dysregulated movement. However, the precise mechanisms by which HIV-1 affects CD4⁺ T cell movement are unknown. Here, we show that HIV-1 infection o

SUBMITTER: Crater JM 

PROVIDER: S-EPMC10888893 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature