Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling.

ABSTRACT: Beta-adrenergic receptors (βARs) are G protein-coupled receptors (GPCRs) that mediate catecholamine-induced stress responses, such as heart rate increase and bronchodilation. In addition to signals from the cell surface, βARs also broadcast non-canonical signaling activities from the cell interior membranes (endomembranes). Dysregulation of these receptor pathways underlies severe pathological conditions. Excessive βAR stimulation is linked to cardiac hypertrophy, leading to heart failure, while impaired stimulation causes compromised fight or flight stress responses and homeostasis. In addition to plasma membrane βAR, emerging evidence indicates potential pathological implications of deeper endomembrane βARs, such as inducing cardiomyocyte hypertrophy and apoptosis, underlying heart failu

SUBMITTER: Thotamune W 

PROVIDER: S-EPMC10888897 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature