A nociceptive amygdala-striatal pathway for chronic pain aversion.

ABSTRACT: The basolateral amygdala (BLA) is essential for assigning positive or negative valence to sensory stimuli. Noxious stimuli that cause pain are encoded by an ensemble of nociceptive BLA projection neurons (BLA ^noci ensemble). However, the role of the BLA ^noci ensemble in mediating behavior changes and the molecular signatures and downstream targets distinguishing this ensemble remain poorly understood. Here, we show that the same BLA ^noci ensemble neurons are required for both acute and chronic neuropathic pain behavior. Using single nucleus RNA-sequencing, we characterized the effect of acute and chronic pain on the BLA and identified enrichment for genes with known functions in axonal and synaptic organization and pain perceptio

SUBMITTER: Wojick JA 

PROVIDER: S-EPMC10888915 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature