Microvascular insulin resistance associates with enhanced muscle glucose disposal in CD36 deficiency.

ABSTRACT: Dysfunction of endothelial insulin delivery to muscle associates with insulin resistance. CD36, a fatty acid transporter and modulator of insulin signaling is abundant in endothelial cells, especially in capillaries. Humans with inherited 50% reduction in CD36 expression have endothelial dysfunction but whether it is associated with insulin resistance is unclear. Using hyperinsulinemic/euglycemic clamps in Cd36^-/- and wildtype mice, and in 50% CD36 deficient humans and matched controls we found that Cd36^-/- mice have enhanced systemic glucose disposal despite unaltered transendothelial insulin transfer and reductions in microvascular perfusion and blood vessel compliance. Partially CD36 deficient humans also have better glucose disposal tha

SUBMITTER: Shibao C 

PROVIDER: S-EPMC10889024 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature