Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease.

ABSTRACT:

Background and objectives

Parkinson's disease (PD) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (SN) and the locus coeruleus (LC), respectively, resulting in motor and cognitive impairments. While SN dopamine dysfunction has clear neurophysiological effects, the impact of reduced LC norepinephrine signaling on brain activity in PD remains to be established.

Methods

We used neuromelanin-sensitive T1-weighted MRI (N_PD = 58; N_HC = 27) and task-free magnetoencephalography (N_PD = 58; N_HC = 65) to identify neuropathophysiological factors related to the degeneration of the LC and SN in patients with PD.

Results

We found pathological increases in rhythmic alpha (8 - 12 Hz)

SUBMITTER: Wiesman AI 

PROVIDER: S-EPMC10889029 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature