Disease progression strikingly differs in research and real-world Parkinson's populations.

ABSTRACT: Characterization of Parkinson's disease (PD) progression using real-world evidence could guide clinical trial design and identify subpopulations. Efforts to curate research populations, the increasing availability of real-world data and recent advances in natural language processing, particularly large language models, allow for a more granular comparison of populations and the methods of data collection describing these populations than previously possible. This study includes two research populations and two real-world data derived (RWD) populations. The research populations are the Harvard Biomarkers Study (HBS, N = 935), a longitudinal biomarkers cohort study with in-person structured study visits; and Fox Insights (N = 36,660), an online self-survey-based research study of the Michael

SUBMITTER: Beaulieu-Jones BK 

PROVIDER: S-EPMC10889035 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature