Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence.

ABSTRACT: Research has identified clinical, genomic, and neurophysiological markers associated with suicide attempts (SA) among individuals with psychiatric illness. However, there is limited research among those with an alcohol use disorder (AUD), despite their disproportionately higher rates of SA. We examined lifetime SA in 4,068 individuals with DSM-IV alcohol dependence from the Collaborative Study on the Genetics of Alcoholism (23% lifetime suicide attempt; 53% female; 17% Admixed African American ancestries; mean age: 38). We 1) conducted a genome-wide association study (GWAS) of SA and performed downstream analyses to determine whether we could identify specific biological pathways of risk, and 2) explored risk in aggregate across other clinical conditions, polygenic scores (PGS) for comorbi

SUBMITTER: Barr P 

PROVIDER: S-EPMC10889049 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature