Molecularly stratified hypothalamic astrocytes are cellular foci for obesity.

ABSTRACT: Astrocytes safeguard the homeostasis of the central nervous system^1,2. Despite their prominent morphological plasticity under conditions that challenge the brain's adaptive capacity^3-5, the classification of astrocytes, and relating their molecular make-up to spatially devolved neuronal operations that specify behavior or metabolism, remained mostly futile^6,7. Although it seems unexpected in the era of single-cell biology, the lack of a major advance in stratifying astrocytes under physiological conditions rests on the incompatibility of 'neurocentric' algorithms that rely on stable developmental endpoints, lifelong transcriptional, neurotransmitter, and neuropeptide signatures for classification^6-8 with the dynamic functional states, anatomic al

SUBMITTER: Harkany T 

PROVIDER: S-EPMC10889077 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature