Sirtuins as Players in the Signal Transduction of Citrus Flavonoids.

ABSTRACT: Sirtuins (SIRTs) belong to the family of nicotine adenine dinucleotide (NAD⁺)-dependent class III histone deacetylases, which come into play in the regulation of epigenetic processes through the deacetylation of histones and other substrates. The human genome encodes for seven homologs (SIRT1-7), which are localized into the nucleus, cytoplasm, and mitochondria, with different enzymatic activities and regulatory mechanisms. Indeed, SIRTs are involved in different physio-pathological processes responsible for the onset of several human illnesses, such as cardiovascular and neurodegenerative diseases, obesity and diabetes, age-related disorders, and cancer. Nowadays, it is well-known that Citrus fruits, typical of the Mediterranean diet, are an important source of bioactive

SUBMITTER: Lombardo GE 

PROVIDER: S-EPMC10889095 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature