Frailty worsens long-term survival in patients with colorectal cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Colorectal cancer (CRC) is the 3^rd most common cancer in men and 2^nd most common malignancy in females across the globe leading to high mortality rates. Frailty is an age-related syndrome that has been associated with high morbidity and mortality. This systematic review aimed to examine if frailty can predict long-term (>1 year) outcomes of patients with CRC.

Methods

This PROSPERO registered review examined the databases of PubMed, Embase, and Web of Science till 4^th September 2023 for cohort studies assessing the association between frailty and long-term outcomes of CRC.

Results

15 studies with 45288 patients were included. 6573 patients (14.5%) were frail. Meta-analysis demonstrated that frailty was associated with statist

SUBMITTER: Han J 

PROVIDER: S-EPMC10889110 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature