The Role of Mechanotransduction in Contact Inhibition of Locomotion and Proliferation.

ABSTRACT: Contact inhibition (CI) represents a crucial tumor-suppressive mechanism responsible for controlling the unbridled growth of cells, thus preventing the formation of cancerous tissues. CI can be further categorized into two distinct yet interrelated components: CI of locomotion (CIL) and CI of proliferation (CIP). These two components of CI have historically been viewed as separate processes, but emerging research suggests that they may be regulated by both distinct and shared pathways. Specifically, recent studies have indicated that both CIP and CIL utilize mechanotransduction pathways, a process that involves cells sensing and responding to mechanical forces. This review article describes the role of mechanotransduction in CI, shedding light on how mechanical forces regulate CIL and CIP.

SUBMITTER: Nakamura F 

PROVIDER: S-EPMC10889191 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature