The Molecular Mechanism of Body Axis Induction in Lampreys May Differ from That in Amphibians.

ABSTRACT: Lamprey homologues of the classic embryonic inducer Noggin are similar in expression pattern and functional properties to Noggin homologues of jawed vertebrates. All noggin genes of vertebrates apparently originated from a single ancestral gene as a result of genome duplications. nogginA, nogginB and nogginC of lampreys, like noggin1 and noggin2 of gnathostomes, demonstrate the ability to induce complete secondary axes with forebrain and eye structures when overexpressed in Xenopus laevis embryos. According to current views, this finding indicates the ability of lamprey Noggin proteins to suppress the activity of the BMP, Nodal/Activin and Wnt/beta-catenin signaling pathways, as shown for Noggin proteins of gnathostomes. In this work, by ana

SUBMITTER: Ermakova GV 

PROVIDER: S-EPMC10889193 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature