Conformational Dynamics of Lipoxygenases and Their Interaction with Biological Membranes.

ABSTRACT: Lipoxygenases (LOXs) are a family of enzymes that includes different fatty acid oxygenases with a common tridimensional structure. The main functions of LOXs are the production of signaling compounds and the structural modifications of biological membranes. These features of LOXs, their widespread presence in all living organisms, and their involvement in human diseases have attracted the attention of the scientific community over the last decades, leading to several studies mainly focused on understanding their catalytic mechanism and designing effective inhibitors. The aim of this review is to discuss the state-of-the-art of a different, much less explored aspect of LOXs, that is, their interaction with lipid bilayers. To this end, the general architecture of six relevant LOXs (namely hu

SUBMITTER: Erba F 

PROVIDER: S-EPMC10889196 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature