Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2.

ABSTRACT: The identification of surfaceome proteins is a main goal in cancer research to design antibody-based therapeutic strategies. T cell engagers based on KLK2, a kallikrein specifically expressed in prostate cancer (PRAD), are currently in early clinical development. Using genomic information from different sources, we evaluated the immune microenvironment and genomic profile of prostate tumors with high expression of KLK2. KLK2 was specifically expressed in PRAD but it was not significant associated with Gleason score. Additionally, KLK2 expression did not associate with the presence of any immune cell population and T cell activating markers. A mild correlation between the high expression of KLK2 and the deletion of TMPRSS2 was identified. KLK2 expression associated with high levels of surfa

SUBMITTER: Paniagua-Herranz L 

PROVIDER: S-EPMC10889228 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature