Dihydromyrcenol Modulates Involucrin Expression through the Akt Signaling Pathway.

ABSTRACT: The epidermis serves as a protective barrier against external threats and is primarily composed of keratinocytes, which ultimately form corneocytes. Involucrin, a protein integral to the cornified envelope, plays a pivotal role in preserving the functional integrity of the skin barrier. Previous studies have shown that Akt plays an important role in keratinocyte differentiation and skin barrier development. This study investigated whether dihydromyrcenol (DHM), a plant-derived terpene, could increase involucrin production in keratinocytes and sought to elucidate the possible underlying mechanisms. To accomplish this objective, we assessed the alterations in involucrin by DHM through quantitative PCR and Western blot on the HaCaT cell line. The changes in the promoter levels were investigat

SUBMITTER: Yang S 

PROVIDER: S-EPMC10889318 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature