A DNA microarray survey of gene expression in normal human tissues.

ABSTRACT:

Background

Numerous studies have used DNA microarrays to survey gene expression in cancer and other disease states. Comparatively little is known about the genes expressed across the gamut of normal human tissues. Systematic studies of global gene-expression patterns, by linking variation in the expression of specific genes to phenotypic variation in the cells or tissues in which they are expressed, provide clues to the molecular organization of diverse cells and to the potential roles of the genes.

Results

Here we describe a systematic survey of gene expression in 115 human tissue samples representing 35 different tissue types, using cDNA microarrays representing approximately 26,000 different human genes. Unsupervised hierarchical cluster analysis of the gene-expression pa

SUBMITTER: Shyamsundar R 

PROVIDER: S-EPMC1088941 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature