Synthesis and Investigations of the Antitumor Effects of First-Row Transition Metal(II) Complexes Supported by Two Fluorinated and Non-Fluorinated β-Diketonates.

ABSTRACT: The 3d transition metal (Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)) complexes, supported by anions of sterically demanding β-diketones, 1,3-dimesitylpropane-1,3-dione (HL^Mes) and 1,3-bis(3,5-bis(trifluoromethyl)phenyl)-3-hydroxyprop-2-en-1-one (HL^CF3), were synthesized and evaluated for their antitumor activity. To assess the biological effects of substituents on phenyl moieties, we also synthesized and investigated the analogous metal(II) complexes of the anion of the less bulky 1,3-diphenylpropane-1,3-dione (HL^Ph) ligand. The compounds [Cu(L^CF3)₂], [Cu(L^Mes)₂] and ([Zn(L^Mes)₂]) were characterized by X-ray crystallography. The [Cu(L^CF3)₂] crystallizes wit

SUBMITTER: Pellei M 

PROVIDER: S-EPMC10889438 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature