Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.

ABSTRACT: We recently reported that transient receptor potential canonical (TRPC) 6 channel activity contributes to intracellular Zn²⁺ homeostasis in the heart. Zn²⁺ has also been implicated in the regulation of intestinal redox and microbial homeostasis. This study aims to investigate the role of TRPC6-mediated Zn²⁺ influx in the stress resistance of the intestine. The expression profile of TRPC1-C7 mRNAs in the actively inflamed mucosa from inflammatory bowel disease (IBD) patients was analyzed using the GEO database. Systemic TRPC3 knockout (KO) and TRPC6 KO mice were treated with dextran sulfate sodium (DSS) to induce colitis. The Zn²⁺ concentration and the mRNA expression levels of oxidative/inflammatory markers in colon tissues were quantitatively an

SUBMITTER: Nishiyama K 

PROVIDER: S-EPMC10889536 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature