Lysophosphatidic Acid Receptor 3 Activation Is Involved in the Regulation of Ferroptosis.

ABSTRACT: Ferroptosis, a unique form of programmed cell death trigged by lipid peroxidation and iron accumulation, has been implicated in embryonic erythropoiesis and aging. Our previous research demonstrated that lysophosphatidic acid receptor 3 (LPA₃) activation mitigated oxidative stress in progeria cells and accelerated the recovery of acute anemia in mice. Given that both processes involve iron metabolism, we hypothesized that LPA₃ activation might mediate cellular ferroptosis. In this study, we used an LPA₃ agonist, 1-Oleoyl-2-O-methyl-rac-glycerophosphothionate (OMPT), to activate LPA₃ and examine its effects on the ferroptosis process. OMPT treatment elevated anti-ferroptosis gene protein expression, including solute carrier family 7 member 11 (SLC

SUBMITTER: Huang YX 

PROVIDER: S-EPMC10889550 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature