Quantitative MRI Evaluation of Ferritin Overexpression in Non-Small-Cell Lung Cancer.

ABSTRACT: Cancer cells frequently present elevated intracellular iron levels, which are thought to facilitate an enhanced proliferative capacity. Targeting iron metabolism within cancer cells presents an avenue to enhance therapeutic responses, necessitating the use of non-invasive models to modulate iron manipulation to predict responses. Moreover, the ubiquitous nature of iron necessitates the development of unique, non-invasive markers of metabolic disruptions to develop more personalized approaches and enhance the clinical utility of these approaches. Ferritin, an iron storage enzyme that is often upregulated as a response to iron accumulation, plays a central role in iron metabolism and has been frequently associated with unfavorable clinical outcomes in cancer. Herein, we demonstrate the succe

SUBMITTER: Singhania M 

PROVIDER: S-EPMC10889593 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature