Preparation and Characterization of Functionalized Surgical Meshes for Early Detection of Bacterial Infections.

ABSTRACT: Isotactic polypropylene (i-PP) nonabsorbable surgical meshes are modified by incorporating a conducting polymer (CP) layer to detect the adhesion and growth of bacteria by sensing the oxidation of nicotinamide adenine dinucleotide (NADH), a metabolite produced by the respiration reactions of such microorganisms, to NAD+. A three-step process is used for such incorporation: (1) treat pristine meshes with low-pressure O₂ plasma; (2) functionalize the surface with CP nanoparticles; and (3) coat with a homogeneous layer of electropolymerized CP using the nanoparticles introduced in (2) as polymerization nuclei. The modified meshes are stable and easy to handle and also show good electrochemical response. The detection by cyclic voltammetry of NADH within the interval of concentratio

SUBMITTER: Fontana-Escartin A 

PROVIDER: S-EPMC10889595 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature