Risk calculator of the clinical response to antihistamines in chronic urticaria: Development and internal validation.

ABSTRACT: Early detection of CSU patients with low probability of a clinical response with antihistamines could undergo prompt initiation of therapeutic alternatives. The aim of the study was to develop and internally validate a model for predicting the clinical response to antihistamines in adult patients with chronic spontaneous urticaria (CSU), who consult allergology and dermatology care centers. A cohort of CSU patients, recruited from four participating centers, were followed up for 12 months. Fifteen candidate variables were selected to be included in the multivariate model and then internal validation was done with bootstrap analysis with 1000 simulations. The outcome variable, clinical response to antihistamines, was evaluated with the UAS (Urticaria Activity Score) scale for seven days: "N

SUBMITTER: Sanchez J 

PROVIDER: S-EPMC10889609 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature