Orthostatic hypotension in stroke/TIA patients: Association with new events and the effect of the NAILED intervention.

ABSTRACT:

Background

Fear of orthostatic hypotension (OH) and a reported association with an increased risk of cardiovascular (CV) events may limit antihypertensive treatment after stroke/TIA. In the NAILED trial, systematic titration of antihypertensive treatment resulted in lower blood pressure (BP) and reduced the incidence of stroke. Our aim was to assess the association between OH and CV events or death in a stroke/TIA population and the association between group allocation in the NAILED trial and risk of OH during follow-up.

Methods and findings

This post-hoc analysis included all patients with complete BP measurement at baseline in the NAILED trial (n = 814). OH was defined as a drop in systolic BP ≥20 or diastolic BP ≥10 mmHg 1 minute after standing from a seated position. The

SUBMITTER: Ogren J 

PROVIDER: S-EPMC10889642 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature