Derivation of genetic interaction networks from quantitative phenotype data.
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ABSTRACT:
SUBMITTER: Drees BL
PROVIDER: S-EPMC1088966 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
Derivation of genetic interaction networks from quantitative phenotype data.
Drees Becky L BL Thorsson Vesteinn V Carter Gregory W GW Rives Alexander W AW Raymond Marisa Z MZ Avila-Campillo Iliana I Shannon Paul P Galitski Timothy T
Genome biology 20050331 4
We have generalized the derivation of genetic-interaction networks from quantitative phenotype data. Familiar and unfamiliar modes of genetic interaction were identified and defined. A network was derived from agar-invasion phenotypes of mutant yeast. Mutations showed specific modes of genetic interaction with specific biological processes. Mutations formed cliques of significant mutual information in their large-scale patterns of genetic interaction. These local and global interaction patterns ...[more]
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